^
Association details:
| Biomarker: | HIF1A overexpression |
|---|---|
| Cancer: | Ovarian Cancer |
| Drug: | telaglenastat (CB-839) (Glutaminase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Targeting glutaminase 1 to sensitize platinum-resistant BRCAwt ovarian cancer to PARP inhibitors
Published date:
03/29/2020
Excerpt:
Treatment of HGSC and clear cell cells with CB-839 resulted in growth arrest and death. CB-839 induced genomic instability in HIF1/HIF2 hyperactivated clear cell ovarian cancer cells and sensitized these tumors to treatment with olaparib.
