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Association details:
| Biomarker: | HIF1A overexpression |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | 5-fluorouracil (Thymidylate synthase inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
ROS/PI3K/Akt and Wnt/ß-catenin signalings activate HIF-1a-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer
Published date:
01/08/2022
Excerpt:
HIF-1α showed enhanced expression in 5-FU-resistant CRC cell lines and clinical specimens, and increased HIF-1α levels were associated with failure of fluorouracil analog-based chemotherapy in CRC patients and poor survival. HIF-1α is a potential biomarker for 5-FU-resistant CRC, and targeting HIF-1a in combination with 5-FU may represent an effective therapeutic strategy in 5-FU-resistant CRC.
DOI:
10.1186/s13046-021-02229-6
