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Association details:
| Biomarker: | HER-2 Y772_A775dup |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug: | Gilotrif (afatinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu
Excerpt:
A 72-year-old, non-smoking female was diagnosed with a stage III lung adenocarcinoma...An exon 20 HER2 mutation (p.Tyr772_Ala775dup; Fig. 1) was found in the tumor DNA extracted from the original diagnostic biopsy...Treatment with afatinib (50 mg/day)...positron emission tomography-CT (PET-CT) imaging showed a radiological partial response (PR) and a metabolic complete response that was maintained for 3 months.
DOI:
https://doi.org/10.1016/j.lungcan.2012.01.008
Trial ID:
