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Association details:
| Biomarker: | HER-2 underexpression |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | VIR-5818 (HER2 inhibitor, CD3 agonist) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
1824 - HER2-XPAT, a novel protease-activatable T-cell engager (TCE) with potent T-cell activation and efficacy in solid tumors and large safety margins in non-human primate (NHP)
Published date:
03/10/2021
Excerpt:
HER2-XPAT was also highly efficacious in the HER2 low-expressing HT-55 colorectal model...HER2-XPAT is a potent, prodrug TCE exhibiting protease-dependent tumor efficacy in mouse xenografts...HER2-XPAT represents a promising solution for HER2-high tumors with potential expansion to HER2 low expressing tumors.
