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Association details:
| Biomarker: | HER-2 mutation |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | Aidixi (disitamab vedotin) (Microtubule inhibitor, HER2-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
A Study of RC48-ADC in Subjects With Advanced Non-small Cell Lung Cancer
Excerpt:
...HER2 protein overexpression (IHC 2+ or 3 +) or HER2 gene mutation (defined as exon 20 mutation), the previous test results confirmed by the researchers, both research centers and major research centers can be acceptable....
Trial ID:
Source:
Title:
A Study of RC48-ADC Combined With Pyrotinib For Treatment of Local Advanced or Metastasis NSCLC With HER2 Mutation
Excerpt:
...- Documented HER2 exon 20 insertion mutation....
Trial ID:
Less C2 evidence
Source:
Title:
588P - First real-world study with HER2 ADC in treating HER2-altered non-small cell lung cancer
Published date:
11/27/2023
Excerpt:
A total of 22 patients with HER2 alterations were enrolled, including 15 with HER2 mutations, 5 with HER2 amplifications, and 2 with both. The overall objective response rate (ORR) was 45.5% (10/22), disease control rate (DCR) was 90.9% (20/22), and median progression-free survival (mPFS) stood at 7.5 months (95% CI 6.6-8.4 months). 95.5% of patients (21/22) underwent combination therapy, yielding an ORR of 47.6% (10/21)....The mPFS was notably prolonged in HER2-amplified patients and anti-HER2 naïve patients....For HER2-altered NSCLC patients, RC48 combined therapies are applicable treatment options, particularly with platinum agents.
