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Association details:
| Biomarker: | HER-2 L755S |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | lapatinib (EGFR inhibitor, HER2 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Differential Sensitivity of ERBB2 Kinase Domain Mutations towards Lapatinib
Excerpt:
In contrast, ERBB2-L755S (IC50>2 µM), ERBB2-L755P (IC50>1.5 µM) and ERBB2-T798M (IC50>1 µM) caused strong lapatinib resistance (Figure 4A and Table 1).
DOI:
10.1371/journal.pone.0026760
