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Association details:
| Biomarker: | HER-2 L755S |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | AEE788 (EGFR inhibitor, HER2 inhibitor, Multi-tyrosine kinase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Differential Sensitivity of ERBB2 Kinase Domain Mutations towards Lapatinib
Excerpt:
Mutations in the ERBB2 receptor have recently been reported in breast cancer at diagnosis and also in gastric, colorectal and lung cancer....While ERBB2-L755S and ERBB2-L755P mutants remained sensitive to AEE788 at very high concentrations (IC90 below 2 µM), the gatekeeper ERBB2-T798M mutation is totally resistant (IC50>2 µM) to AEE788 treatment.
DOI:
10.1371/journal.pone.0026760
