^
Association details:
| Biomarker: | HER-2 G776S |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | Gilotrif (afatinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
HER2 G776S mutation promotes oncogenic potential in colorectal cancer cells when accompanied by loss of APC function
Published date:
06/02/2022
Excerpt:
...afatinib, a pan-HER tyrosine kinase inhibitor, suppressed tumor growth in xenografts derived from HER2 G776S-transfected CRC cells.
DOI:
10.1038/s41598-022-13189-y
