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Association details:
| Biomarker: | HER-2 G776insV_C |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | Nerlynx (neratinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Non–Small-Cell Lung Cancer and Ba/F3 Transformed Cells Harboring the ERBB2 G776insV_G/C Mutation Are Sensitive to the Dual-Specific Epidermal Growth Factor Receptor and ERBB2 Inhibitor HKI-272
Excerpt:
In contrast, NCI-H1781 cells, known to carry wild-type EGFR and the G776insV_G/C mutation of ERBB2 ( 9), were resistant to erlotinib. However, these cells were highly sensitive to HKI-272 with an IC50 of 0.085 μmol/L.
DOI:
10.1158/0008-5472.CAN-06-0971
