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    Association details:
    Biomarker:HER-2 expression
    Cancer:HER2 Positive Breast Cancer
    Drug:BAY2701439 (HER2 inhibitor, Alpha radiation emitter)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Cancers (Basel)
    Title:

    Efficacy of a HER2-Targeted Thorium-227 Conjugate in a HER2-Positive Breast Cancer Bone Metastasis Model

    Published date:
    06/29/2023
    Excerpt:
    In vitro, HER2-TTC showed potent cytotoxicity in various HER2-expressing cancer cell lines...In vivo, HER2-TTC demonstrated dose-dependent antitumor efficacy in subcutaneous xenograft models….These results demonstrate proof-of-concept for TAT in the treatment of patients with HER2-positive breast cancer, including cases where the tumor has metastasized to bone.
    DOI:
    10.3390/cancers15133419