We reviewed patients with advanced NSCLC with EGFR/HER2 exon 20 insertion mutations...In the first-line treatment,bevacizumab + chemotherapy (Beva+Chemo), ICI+chemotherapy (ICI+Chemo) , compared with chemotherapy alone (Chemo), ORR: 40% vs 33.3% vs 15% (p=0.0168 ); DCR: 84% vs 80.9% vs 67.5% (p=0.1817); median PFS: 8.3 vs 7.0 vs 4.6 months (p=0.0032), ICI+Chemo has a trend of benefiting on OS....For patients with EGFR20ins mutation, ICI+Chemo significantly prolonged PFS, and after chemotherapy progression, bevacizumab combined with chemotherapy is markedly better than Furmonertinib-based targeted therapy. For HER2-20ins mutation, Beva+Chemo is a better choice.