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Association details:
| Biomarker: | HDAC1 amplification |
|---|---|
| Cancer: | Soft Tissue Sarcoma |
| Drug: | Epidaza (chidamide) (PI3K inhibitor, AKT inhibitor, HDAC inhibitor, HDAC1 inhibitor, HDAC2 inhibitor, HDAC3 inhibitor, MAPK inhibitor, HDAC10 inhibitor) |
| Drug Class: | PD1 inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma
Published date:
02/26/2021
Excerpt:
HDAC class I gene amplification with STS patients who achieved a PR, indicating that chidamide combined with an anti-PD-1 antibody shows a promise as treatment for patients with frequent HDAC amplification in the future.
DOI:
10.1136/jitc-2020-001696
