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Association details:
| Biomarker: | GOLGA4-RAF1 fusion |
|---|---|
| Cancer: | Cutaneous Melanoma |
| Drug Class: | MEK inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Profound MEK inhibitor response in a cutaneous melanoma harboring a GOLGA4-RAF1 fusion
Published date:
04/02/2019
Excerpt:
We describe a metastatic melanoma with a GOLGA4-RAF1 fusion...In the absence of other actionable variants, the patient was administered MEK inhibitor therapy on the basis of its potential action against RAF1 fusions. This resulted in a profound and clinically significant response.
DOI:
10.1172/JCI123089
