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Association details:
| Biomarker: | GNA13 deletion + TP53 mutation |
|---|---|
| Cancer: | Pancreatic Cancer |
| Drug: | sirolimus (mTOR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Ga13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin
Published date:
03/01/2022
Excerpt:
Here, we show that loss of Gα13 in the Kras/Tp53 (KPC) GEM model...Treatment with the mTOR inhibitor rapamycin decreases the growth of syngeneic KPC tumors with Gα13 loss by promoting cell death.
DOI:
10.1016/j.celrep.2022.110441
