^
Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

Ga13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin

Published date:
03/01/2022
Excerpt:
Here, we show that loss of Gα13 in the Kras/Tp53 (KPC) GEM model...Treatment with the mTOR inhibitor rapamycin decreases the growth of syngeneic KPC tumors with Gα13 loss by promoting cell death.
DOI:
10.1016/j.celrep.2022.110441