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Association details:
| Biomarker: | GNA11 Q209L |
|---|---|
| Cancer: | Uveal Melanoma |
| Drug: | darovasertib (IDE196) (PKC inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Circulating tumor DNA (ctDNA) in patients (pts) with metastatic uveal melanoma (UM) treated with protein kinase C inhibitor (PKCi).
Published date:
05/28/2020
Excerpt:
16/17 pts had paired samples at baseline and EOT and only 4/16 pts were undetectable at EOT. These 4 pts were GNA11 Q209L positive, had below median SPOD (median 5986, range 200 – 16782), and low numbers of liver metastases (median 9, range 1 – 49). Of these 4 pts, one had PR and three had SD (two with SD > 6 months) as best response.
DOI:
10.1200/JCO.2020.38.15_suppl.e22054
