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    Association details:
    Biomarker:GNA11 Q209L
    Cancer:Uveal Melanoma
    Drug:darovasertib (IDE196) (PKC inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    New
    Source:
    ASCO 2020
    Title:

    Circulating tumor DNA (ctDNA) in patients (pts) with metastatic uveal melanoma (UM) treated with protein kinase C inhibitor (PKCi).

    Published date:
    05/28/2020
    Excerpt:
    16/17 pts had paired samples at baseline and EOT and only 4/16 pts were undetectable at EOT. These 4 pts were GNA11 Q209L positive, had below median SPOD (median 5986, range 200 – 16782), and low numbers of liver metastases (median 9, range 1 – 49). Of these 4 pts, one had PR and three had SD (two with SD > 6 months) as best response.
    DOI:
    10.1200/JCO.2020.38.15_suppl.e22054