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Association details:
| Biomarker: | FLT3 N676D + FLT3 Y842C |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | Vanflyta (quizartinib) (FLT3 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Reversal of Acquired Drug Resistance in FLT3-mutated Acute Myeloid Leukemia Cells via Distinct Drug Combination Strategies
Excerpt:
AC220 demonstrated a similar pattern of resistance as observed with sorafenib treatment (Fig. 2A).
DOI:
https://dx.doi.org/10.1158%2F1078-0432.CCR-13-2052