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Association details:
| Biomarker: | FLT3 mutation |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | OTS167 (MELK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
OTS167 blocks FLT3 translation and synergizes with FLT3 inhibitors in FLT3 mutant acute myeloid leukemia
Published date:
03/03/2021
Excerpt:
The MELK inhibitor OTS167 induces cell death in AML including cells with FLT3 mutations...OTS167 in combination with TKIs results in synergistic induction of FLT3 mutant cell death in FLT3 mutant cell lines and prolonged survival in a FLT3 mutant AML xenograft mouse model.
Secondary therapy:
Tyrosine Kinase inhibitors
DOI:
10.1038/s41408-021-00433-3