Evidence Level:Sensitive: C2 – Inclusion Criteria
Title:
China Children's Leukemia Group (CCLG)-AML2019 supplementary study on pediatric acute myeloid leukemia-Gilteritinib therapy
Excerpt:...Patients with FLT3-mutated....
Evidence Level:Sensitive: C2 – Inclusion Criteria
Title:
A Study of ASP2215 (Gilteritinib) Combined With Atezolizumab in Patients With Relapsed or Treatment Refractory FMS-like Tyrosine Kinase (FLT3) Mutated Acute Myeloid Leukemia (AML)
Excerpt:...- Subject is positive for FLT3 mutation in bone marrow or blood after completion of the subject's last interventional treatment....
More C2 evidence
Evidence Level:Sensitive: C2 – Inclusion Criteria
Title:
A Non-interventional Ambispective Real-world Cohort of rEfractory and reLapsed (R/R) FLT3 Mutated Acute MyEloid Leukemia (AML) Patients Treated With Gilteritinib in FrANCE
Excerpt:...best response obtained according to European Leukemia Net (ELN) 2017 recommendations and ADMIRAL definitions effectiveness will also described in the following subgroups : refractory after 1st line chemo, 1rst relapse = 6 months after CR1, refractory after 1 st relapse salvage treatment, beyond the first relapse (>= 2nd relapse), post Hematopoietic Stem Cell Transplantation (HSCT), post 1L midostaurine and by ELN 2017 risk groups`Gilteritinib effectiveness in FLT3-mutated AML patients in R/R situation...
Evidence Level:Sensitive: C2 – Inclusion Criteria
Title:
A Study of ASP2215 (Gilteritinib) by Itself, ASP2215 Combined With Azacitidine or Azacitidine by Itself to Treat Adult Patients Who Have Recently Been Diagnosed With Acute Myeloid Leukemia With a FLT3 Gene Mutation and Who Cannot Receive Standard Chemotherapy
Excerpt:...- Subject is positive for FLT3 mutation (internal tandem duplication [ITD] or tyrosine kinase domain [TKD] [D835/I836] mutation) (or for...
Evidence Level:Sensitive: C2 – Inclusion Criteria
Title:
A Study of ASP2215 Versus Salvage Chemotherapy In Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) With FLT3 Mutation
Excerpt:...- Subject is positive for FLT3 mutation in bone marrow or whole blood as determined by the central lab....
Evidence Level:Sensitive: C2 – Inclusion Criteria
Title:
A Study of Gilteritinib, Venetoclax and Azacitidine as a Combined Treatment for People Newly Diagnosed With Acute Myeloid Leukemia
Excerpt:...- Participant is positive for FMS-like tyrosine kinase 3 (FLT3) mutation (internal tandem duplication [ITD] and/or tyrosine kinase domain [TKD] [D835/I836] mutation) in bone marrow or whole blood as determined by the central laboratory....
Evidence Level:Sensitive: C2 – Inclusion Criteria
Title:
A Study of ASP2215 Versus Salvage Chemotherapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) With FMS-like Tyrosine Kinase (FLT3) Mutation
Excerpt:...- Participant is positive for FLT3 mutation in bone marrow or whole blood as determined by the central lab....
Evidence Level:Sensitive: C2 – Inclusion Criteria
Title:
Individual Patient Expanded Access Gilteritinib (ASP2215)
Excerpt:...Subject has presence of the FLT3 mutation (internal tandem duplication [ITD] and/or tyrosine kinase domain [TKD] [D835/I836] mutation) in bone marrow or peripheral blood as determined by local laboratory....
Evidence Level:Sensitive: C2 – Inclusion Criteria
Title:
Expanded Access Study of Gilteritinib (ASP2215) in Patients With FMS-like Tyrosine Kinase 3 (FLT3) Mutated Relapsed or Refractory Acute Myeloid Leukemia (AML) or FLT3-Mutated AML in Complete Remission (CR) With Minimal Residual Disease (MRD)
Excerpt:...- Subject has presence of the FLT3-mutated relapsed or refractory AML or FLT3-mutated AML in CRc (CR, CRi, CRp) with MRD in bone marrow or peripheral blood....
Evidence Level:Sensitive: C2 – Inclusion Criteria
Title:
Early Access Program (EAP) of Gilteritinib (ASP2215) in Patients With FMS-like Tyrosine Kinase 3 (FLT3) Mutated Relapsed or Refractory Acute Myeloid Leukemia (AML) or With FLT3-Mutated AML in Complete Remission (CR) With Minimal Residual Disease (MRD)
Excerpt:...- Patient has presence of the FLT3 mutation (internal tandem duplication and/or tyrosine kinase domain [D835/I836] mutation) in bone marrow or peripheral blood....
Evidence Level:Sensitive: C2 – Inclusion Criteria
Title:
A study of Gilteritinib combined with chemotherapy to treat Children, Adolescents and Young Adults with Relapsed or Refractory Acute Myeloid Leukemia (AML) with a FLT3 gene mutation
Excerpt:...El sujeto muestra positividad de mutación FLT3/ITD en médula ósea o en sangre en el estudio practicado por el centro local.3. ...
Less C2 evidence
Evidence Level:Sensitive: D – Preclinical
Title:
Multi-Modal Targeting of FLT3 with Chimeric Antigen Receptor T Cell Immunotherapy and Tyrosine Kinase Inhibition in High-Risk Pediatric Leukemias
Excerpt:Taken together, our preclinical studies demonstrate that dual targeting with FLT3CART immunotherapy and gilteritinib is a promising therapeutic strategy in FLT3-mutant AML and, importantly, also in KMT2A-R ALL.
DOI:10.1182/blood-2021-147321