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Association details:
| Biomarker: | FLT3-ITD mutation |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | itacnosertib (TP-0184) (ACVR1 inhibitor, TGF-β RI antagonist) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Novel FLT3-ALK2 Dual Inhibitor TP-0184 Inhibits Leukemia Growth by Targeting Serine Biosynthesis in FLT3 ITD-Positive AML Cells
Published date:
09/21/2022
Excerpt:
Lastly, treatment with TP-0184 significantly prolonged the survival of FLT3-ITD–mutated AML-bearing mice (P<0.0001)….TP-0184 inhibits AML growth in FLT3-mutated PDX and xenograft models.
