^
Association details:
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

TRIPLE COMBINATION OF HMA, VENETOCLAX, AND FLT3 INHIBITOR PRODUCES HIGHER FLT3 PCR CLEARANCE, FLOW MRD NEGATIVITY, AND IMPROVED MEDIAN OS COMPARED WITH DOUBLETS OF HMA WITH FLT3 INHIBITOR

Published date:
05/12/2021
Excerpt:
We identified 77 adult pts with newly diagnosed FLT3m (ITD and/or TKD) AML who were treated with LIC including first-generation (sorafenib, midostaurin) LIC doublet (n=44), second-generation (quizartinib) LIC doublet (n=16), and HMA-VEN-FLT3i (sorafenib, gilteritinib, midostaurin) triplet (n=17)....With a median follow-up of 28 months, pts treated with triplets achieved the best median OS compared with pts treated with first- or second-generation FLT3i based LIC doublets (not reached vs 15.7 vs 8.7 months (m), respectively, p=0.01)
Secondary therapy:
midostaurin