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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

1283 FLT3-ITD Degrades CEBPA Via the Ubiquitin-Proteosome Pathway

Published date:
11/03/2022
Excerpt:
FLT3-ITD AML cells were >2-fold more sensitive to P22077 than FLT3-wt AML cells (IC50 5.8 and 7.1 µM for MV411 and MOLM13 versus 13.65 and 21.7 µM for THP1 and K562 cells).
DOI:
https://doi.org/10.1182/blood-2022-166612