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Association details:
| Biomarker: | FLT3-ITD mutation |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | LAM 003 (HSP90 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
LAM-003, a Novel Oral Heat Shock Protein 90 Inhibitor for Treatment of Acute Myeloid Leukemia, Including Wild-Type and FMS-like Tyrosine Kinase 3 (FLT3)-Mutant Disease
Published date:
11/06/2019
Excerpt:
LAM-003 inhibited proliferation of both FLT3-mutant and wild-type cell lines, with preferential activity against cells harboring FLT3-ITD…. Additionally, we observed that LAM-003 was potent in a subset of the FLT3 WT cells.
DOI:
10.1182/blood-2019-125770
