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Association details:
| Biomarker: | FLT3-ITD mutation |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | bortezomib (Proteasome inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Inhibition of the proteasome and proteaphagy enhances apoptosis in FLT3-ITD-driven acute myeloid leukemia
Published date:
08/15/2020
Excerpt:
...the higher apoptosis observed for the Bz treatment only. Cooperative effects observed with the double Bz/VT treatment were statistically significant in MOLM‐14 cells but not in OCI‐AML3 (Fig. 5E,F). Taken together, our results show that the inhibition of both proteolytic pathways markedly enhances apoptosis levels in MOLM‐14 that express FLT3‐ITD (Fig. 6) but not in OCI‐AML3 that express WT FLT3.
DOI:
https://doi.org/10.1002/2211-5463.12950
