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Association details:
| Biomarker: | FLT3-ITD mutation + SKI overexpression |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug Class: | HDAC inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
THE ONCOPROTEIN SKI IS ASSOCIATED WITH A SHORTER OVERALL SURVIVAL IN ACUTE MYELOID LEUKEMIA PATIENTS WITH NORMAL KARYOTYPE AND A MUTATED RECEPTOR TYROSINE KINASE FLT3ITD
Published date:
05/14/2020
Excerpt:
Since FLT3ITD-positive AML cells with a high SKI expression respond better to HDACi, an additional treatment with HDACi may provide a therapeutic benefit for FLT3ITD-positive CN AML patients with a high SKI expression.
