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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Source:
Title:

Prediction of Resistance to Small Molecule FLT3 Inhibitors

Excerpt:
Mutations at four different positions (Ala-627, Asn-676, Phe-691, and Gly-697) were identified that confer varying degrees of resistance to PKC412, SU5614, or K-252a. FLT3 proteins mutated at Ala-627, Asn-676, or Phe-691 remained sensitive to higher concentrations of the inhibitors, but the G697R mutation conferred high-level resistance to each of these inhibitors as well as to six additional experimental inhibitors.
DOI:
10.1158/0008-5472.CAN-04-2148