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Association details:
| Biomarker: | FLT3 D835Y |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | BGS-2456 (FLT3 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
2265 BGS-2456 Is a Novel Potent Covalent Inhibitor of FLT3 That Highly Discriminates Against KIT and Is Not Toxic Toward Normal Hematopoiesis in Vitro
Published date:
11/02/2023
Excerpt:
...we assessed BGS-2456’s ability to retain activity against the known clinically problematic drug-resistant FLT3-ITD mutants D835Y and F691L. Encouragingly, BGS-2456 retained activity against both D835Y and F691L mutants in the low nanomolar range.
