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Association details:
| Biomarker: | FGFR3 overexpression |
|---|---|
| Cancer: | Squamous Cell Carcinoma of Head and Neck |
| Drug: | Truseltiq (infigratinib) (FGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Evaluation of FGFR3 as a Therapeutic Target in Head and Neck Squamous Cell Carcinoma
Excerpt:
FGFR3 protein expression was analysed in a large HNSCC tissue cohort (n = 536) and FGFR3 mRNA expression…Moreover, FGFR3-overexpressing cells were more sensitive to BGJ398...Cells overexpressing FGFR3 mutant versions showed increased proliferation compared to wild-type FGFR3 under serum-reduced conditions and were largely as sensitive as the wild-type protein to BGJ398.
DOI:
10.1007/s11523-016-0431-z
