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Association details:
| Biomarker: | FGFR2-NRAP fusion |
|---|---|
| Cancer: | Cholangiocarcinoma |
| Drug: | Truseltiq (infigratinib) (FGFR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
TAS-120 overcomes resistance to ATP-competitive FGFR inhibitors in patients with FGFR2 fusion-positive intrahepatic cholangiocarcinoma
Excerpt:
...a 46-year-old male with chronic hepatitis B and recurrent metastatic FGFR2-NRAP fusion-positive ICC involving his liver. Second-line BGJ398 led to a maximum response of −40% but at approximately 7 months, scans showed a mixed response with continued tumor shrinkage in the liver and emergence of osseous metastases.
DOI:
https://dx.doi.org/10.1158%2F2159-8290.CD-19-0182
