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BIOMARKER:
FGFR2 mutation
i
Other names:
FGFR2, BEK, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, Fibroblast growth factor receptor 2
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Entrez ID:
2263
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
FGFR2 overexpression (8)
FGFR2 expression (3)
FGFR2b expression (3)
FGFR2b overexpression (2)
FGFR2b overexpression + HER-2 negative (2)
FGFR2b positive (2)
FGFR2 underexpression (1)
FGFR2 underexpression + FGFR3 overexpression (1)
FGFR2 underexpression + FGFR3 expression (0)
HER-2 negative + FGFR2b overexpression (0)
FGFR2 overexpression (8)
FGFR2 expression (3)
FGFR2b expression (3)
FGFR2b overexpression (2)
FGFR2b overexpression + HER-2 negative (2)
FGFR2b positive (2)
FGFR2 underexpression (1)
FGFR2 underexpression + FGFR3 overexpression (1)
FGFR2 underexpression + FGFR3 expression (0)
HER-2 negative + FGFR2b overexpression (0)
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VERI cancer hierarchy
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FGFR2 mutation
Urothelial Cancer
FGFR2 mutation
Urothelial Cancer
erdafitinib
Sensitive: A1 - Approval
erdafitinib
Sensitive
:
A1
erdafitinib
Sensitive: A1 - Approval
erdafitinib
Sensitive
:
A1
FGFR2 mutation
Cholangiocarcinoma
FGFR2 mutation
Cholangiocarcinoma
KIN-3248
Sensitive: B - Late Trials
KIN-3248
Sensitive
:
B
KIN-3248
Sensitive: B - Late Trials
KIN-3248
Sensitive
:
B
FGFR2 mutation
Cholangiocarcinoma
FGFR2 mutation
Cholangiocarcinoma
erdafitinib
Sensitive: C1 - Off-label
erdafitinib
Sensitive
:
C1
erdafitinib
Sensitive: C1 - Off-label
erdafitinib
Sensitive
:
C1
FGFR2 mutation
Gastric Cancer
FGFR2 mutation
Gastric Cancer
erdafitinib
Sensitive: C1 - Off-label
erdafitinib
Sensitive
:
C1
erdafitinib
Sensitive: C1 - Off-label
erdafitinib
Sensitive
:
C1
FGFR2 mutation
Solid Tumor
FGFR2 mutation
Solid Tumor
erdafitinib
Sensitive: C1 - Off-label
erdafitinib
Sensitive
:
C1
erdafitinib
Sensitive: C1 - Off-label
erdafitinib
Sensitive
:
C1
FGFR2 mutation
Bladder Cancer
FGFR2 mutation
Bladder Cancer
erdafitinib
Sensitive: C1 - Off-label
erdafitinib
Sensitive
:
C1
erdafitinib
Sensitive: C1 - Off-label
erdafitinib
Sensitive
:
C1
FGFR2 mutation
Cholangiocarcinoma
FGFR2 mutation
Cholangiocarcinoma
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
FGFR2 mutation
Cholangiocarcinoma
FGFR2 mutation
Cholangiocarcinoma
ARQ 087
Sensitive: C2 – Inclusion Criteria
ARQ 087
Sensitive
:
C2
ARQ 087
Sensitive: C2 – Inclusion Criteria
ARQ 087
Sensitive
:
C2
FGFR2 mutation
Cholangiocarcinoma
FGFR2 mutation
Cholangiocarcinoma
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
FGFR2 mutation
Cholangiocarcinoma
FGFR2 mutation
Cholangiocarcinoma
TT-00420
Sensitive: C2 – Inclusion Criteria
TT-00420
Sensitive
:
C2
TT-00420
Sensitive: C2 – Inclusion Criteria
TT-00420
Sensitive
:
C2
FGFR2 mutation
Solid Tumor
FGFR2 mutation
Solid Tumor
TT-00420
Sensitive: C2 – Inclusion Criteria
TT-00420
Sensitive
:
C2
TT-00420
Sensitive: C2 – Inclusion Criteria
TT-00420
Sensitive
:
C2
FGFR2 mutation
Non Small Cell Lung Cancer
FGFR2 mutation
Non Small Cell Lung Cancer
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
FGFR2 mutation
Non Small Cell Lung Cancer
FGFR2 mutation
Non Small Cell Lung Cancer
nintedanib
Sensitive: C3 – Early Trials
nintedanib
Sensitive
:
C3
nintedanib
Sensitive: C3 – Early Trials
nintedanib
Sensitive
:
C3
FGFR2 mutation
Cholangiocarcinoma
FGFR2 mutation
Cholangiocarcinoma
pemigatinib
Sensitive: C3 – Early Trials
pemigatinib
Sensitive
:
C3
pemigatinib
Sensitive: C3 – Early Trials
pemigatinib
Sensitive
:
C3
FGFR2 mutation
Cholangiocarcinoma
FGFR2 mutation
Cholangiocarcinoma
FGFR2 inhibitor
Resistant: C3 – Early Trials
FGFR2 inhibitor
Resistant
:
C3
FGFR2 inhibitor
Resistant: C3 – Early Trials
FGFR2 inhibitor
Resistant
:
C3
FGFR2 mutation
Cholangiocarcinoma
FGFR2 mutation
Cholangiocarcinoma
Debio 1347
Sensitive: C3 – Early Trials
Debio 1347
Sensitive
:
C3
Debio 1347
Sensitive: C3 – Early Trials
Debio 1347
Sensitive
:
C3
FGFR2 mutation
Melanoma
FGFR2 mutation
Melanoma
PD1 inhibitor
Sensitive: C3 – Early Trials
PD1 inhibitor
Sensitive
:
C3
PD1 inhibitor
Sensitive: C3 – Early Trials
PD1 inhibitor
Sensitive
:
C3
FGFR2 mutation
Melanoma
FGFR2 mutation
Melanoma
CTLA4 inhibitor
Sensitive: C3 – Early Trials
CTLA4 inhibitor
Sensitive
:
C3
CTLA4 inhibitor
Sensitive: C3 – Early Trials
CTLA4 inhibitor
Sensitive
:
C3
FGFR2 mutation
Melanoma
FGFR2 mutation
Melanoma
PD-L1 inhibitor
Sensitive: C3 – Early Trials
PD-L1 inhibitor
Sensitive
:
C3
PD-L1 inhibitor
Sensitive: C3 – Early Trials
PD-L1 inhibitor
Sensitive
:
C3
FGFR2 mutation
Urothelial Cancer
FGFR2 mutation
Urothelial Cancer
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
FGFR2 mutation
Solid Tumor
FGFR2 mutation
Solid Tumor
futibatinib
Sensitive: C3 – Early Trials
futibatinib
Sensitive
:
C3
futibatinib
Sensitive: C3 – Early Trials
futibatinib
Sensitive
:
C3
FGFR2 mutation
Solid Tumor
FGFR2 mutation
Solid Tumor
CPL304110
Sensitive: D – Preclinical
CPL304110
Sensitive
:
D
CPL304110
Sensitive: D – Preclinical
CPL304110
Sensitive
:
D
FGFR2 mutation
Multiple Myeloma
FGFR2 mutation
Multiple Myeloma
infigratinib
Sensitive: D – Preclinical
infigratinib
Sensitive
:
D
infigratinib
Sensitive: D – Preclinical
infigratinib
Sensitive
:
D
FGFR2 mutation
Endometrial Cancer
FGFR2 mutation
Endometrial Cancer
infigratinib
Sensitive: D – Preclinical
infigratinib
Sensitive
:
D
infigratinib
Sensitive: D – Preclinical
infigratinib
Sensitive
:
D
FGFR2 mutation
Endometrial Cancer
FGFR2 mutation
Endometrial Cancer
PD173074
Sensitive: D – Preclinical
PD173074
Sensitive
:
D
PD173074
Sensitive: D – Preclinical
PD173074
Sensitive
:
D
FGFR2 mutation
Endometrial Cancer
FGFR2 mutation
Endometrial Cancer
TKI258
Sensitive: D – Preclinical
TKI258
Sensitive
:
D
TKI258
Sensitive: D – Preclinical
TKI258
Sensitive
:
D
FGFR2 mutation
Estrogen Receptor Positive Breast Cancer
FGFR2 mutation
Estrogen Receptor Positive Breast Cancer
fulvestrant
Resistant: D – Preclinical
fulvestrant
Resistant
:
D
fulvestrant
Resistant: D – Preclinical
fulvestrant
Resistant
:
D
FGFR2 mutation
Estrogen Receptor Positive Breast Cancer
FGFR2 mutation
Estrogen Receptor Positive Breast Cancer
palbociclib
Resistant: D – Preclinical
palbociclib
Resistant
:
D
palbociclib
Resistant: D – Preclinical
palbociclib
Resistant
:
D
FGFR2 mutation
Solid Tumor
FGFR2 mutation
Solid Tumor
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
FGFR2 mutation
Gastric Cancer
FGFR2 mutation
Gastric Cancer
KIN-3248
Sensitive: D – Preclinical
KIN-3248
Sensitive
:
D
KIN-3248
Sensitive: D – Preclinical
KIN-3248
Sensitive
:
D
^
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