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Association details:
| Biomarker: | FGFR1-G3BP2 fusion |
|---|---|
| Cancer: | Pancreatic Cancer |
| Drug: | elimusertib (BAY 1895344) (ATR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Whole exome and transcriptome sequencing of colorectal and pancreatic cancer.
Published date:
05/28/2020
Excerpt:
A 52 year-old male met Stage IV PC, was treated with rucaparib and irinotecan based on prior sequencing data. Upon relapse, the pt went on ATR inhibitor (BAY1895344) and progressed very quickly. Sequencing of the met lesion was found to harbor FGFR1/G3BP2 fusion which was also confirmed by RNA expression.
DOI:
10.1200/JCO.2020.38.15_suppl.e15666
