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Association details:
| Biomarker: | FGFR1 amplification |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | PD173074 (Tyrosine kinase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial
Excerpt:
...FGFR2 high-level amplified cell lines were more sensitive to the FGFR inhibitors AZD4547 and PD173074 in vitro than low-level FGFR1-amplified cell lines, both in terms of lower EC50 and increased maximal effect (Fig. 3C and D).
DOI:
10.1158/2159-8290.CD-15-1246
