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GENE:
FGF3 (Fibroblast growth factor 3)
i
Other names:
FGF3, Fibroblast Growth Factor 3, V-INT2 Murine Mammary Tumor Virus Integration Site Oncogene Homolog, Murine Mammary Tumor Virus Integration Site 2, Heparin-Binding Growth Factor 3, INT-2 Proto-Oncogene Protein, Proto-Oncogene Int-2, Oncogene INT2, HBGF-3, INT2
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Entrez ID:
2248
Associations
(14)
News
Trials
VERI cancer hierarchy
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FGF3 amplification + ER positive
HER2 Negative Breast Cancer
FGF3 amplification + ER positive
HER2 Negative Breast Cancer
palbociclib + PF-05212384
Sensitive: C3 – Early Trials
palbociclib + PF-05212384
Sensitive
:
C3
palbociclib + PF-05212384
Sensitive: C3 – Early Trials
palbociclib + PF-05212384
Sensitive
:
C3
EGFR L858R + FGF3 mutation
Non Small Cell Lung Cancer
EGFR L858R + FGF3 mutation
Non Small Cell Lung Cancer
osimertinib
Resistant: C3 – Early Trials
osimertinib
Resistant
:
C3
osimertinib
Resistant: C3 – Early Trials
osimertinib
Resistant
:
C3
FGF3 amplification
Hepatocellular Cancer
FGF3 amplification
Hepatocellular Cancer
sorafenib
Sensitive: C3 – Early Trials
sorafenib
Sensitive
:
C3
sorafenib
Sensitive: C3 – Early Trials
sorafenib
Sensitive
:
C3
FGF3 amplification
Breast Cancer
FGF3 amplification
Breast Cancer
TKI258
Sensitive: C3 – Early Trials
TKI258
Sensitive
:
C3
TKI258
Sensitive: C3 – Early Trials
TKI258
Sensitive
:
C3
FGF3 mutation
Urothelial Cancer
FGF3 mutation
Urothelial Cancer
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
FGF3 overexpression
Hepatocellular Cancer
FGF3 overexpression
Hepatocellular Cancer
sorafenib
Sensitive: C4 – Case Studies
sorafenib
Sensitive
:
C4
sorafenib
Sensitive: C4 – Case Studies
sorafenib
Sensitive
:
C4
FGF3 mutation
Estrogen Receptor Positive Breast Cancer
FGF3 mutation
Estrogen Receptor Positive Breast Cancer
palbociclib
Resistant: D – Preclinical
palbociclib
Resistant
:
D
palbociclib
Resistant: D – Preclinical
palbociclib
Resistant
:
D
FGF3 mutation
Estrogen Receptor Positive Breast Cancer
FGF3 mutation
Estrogen Receptor Positive Breast Cancer
fulvestrant
Resistant: D – Preclinical
fulvestrant
Resistant
:
D
fulvestrant
Resistant: D – Preclinical
fulvestrant
Resistant
:
D
FGF3 amplification + HRAS Q61R + TP53 672+2T>G
Prostate Cancer
FGF3 amplification + HRAS Q61R + TP53 672+2T>G
Prostate Cancer
APR-246
Sensitive: D – Preclinical
APR-246
Sensitive
:
D
APR-246
Sensitive: D – Preclinical
APR-246
Sensitive
:
D
FGF3 amplification + HRAS Q61R + TP53 672+2T>G
Prostate Cancer
FGF3 amplification + HRAS Q61R + TP53 672+2T>G
Prostate Cancer
MK-2206
Sensitive: D – Preclinical
MK-2206
Sensitive
:
D
MK-2206
Sensitive: D – Preclinical
MK-2206
Sensitive
:
D
FGF3 amplification + HRAS Q61R + TP53 672+2T>G
Prostate Cancer
FGF3 amplification + HRAS Q61R + TP53 672+2T>G
Prostate Cancer
tipifarnib
Sensitive: D – Preclinical
tipifarnib
Sensitive
:
D
tipifarnib
Sensitive: D – Preclinical
tipifarnib
Sensitive
:
D
FGF3 amplification + HRAS Q61R + TP53 672+2T>G
Prostate Cancer
FGF3 amplification + HRAS Q61R + TP53 672+2T>G
Prostate Cancer
erdafitinib
Sensitive: D – Preclinical
erdafitinib
Sensitive
:
D
erdafitinib
Sensitive: D – Preclinical
erdafitinib
Sensitive
:
D
FGF3 amplification + HRAS Q61R + TP53 672+2T>G
Prostate Cancer
FGF3 amplification + HRAS Q61R + TP53 672+2T>G
Prostate Cancer
INNO-406
Sensitive: D – Preclinical
INNO-406
Sensitive
:
D
INNO-406
Sensitive: D – Preclinical
INNO-406
Sensitive
:
D
FGF3 amplification + HRAS Q61R + TP53 672+2T>G
Prostate Cancer
FGF3 amplification + HRAS Q61R + TP53 672+2T>G
Prostate Cancer
abemaciclib
Sensitive: D – Preclinical
abemaciclib
Sensitive
:
D
abemaciclib
Sensitive: D – Preclinical
abemaciclib
Sensitive
:
D
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