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    Association details:
    Biomarker:FAT1 mutation
    Cancer:Squamous Cell Carcinoma of Head and Neck
    Drug:JQ-1 (BET inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Cell Rep
    Title:

    YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4

    Published date:
    06/14/2022
    Excerpt:
    Comprehensive proteomic and drug-screening studies across pan-cancer models confirm that FAT1-mutant HNSCC exhibits selective and higher sensitivity to BRD4 inhibition by JQ1.
    DOI:
    10.1016/j.celrep.2022.110970