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Association details:
| Biomarker: | FAT1 mutation |
|---|---|
| Cancer: | Squamous Cell Carcinoma of Head and Neck |
| Drug: | JQ-1 (BET inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4
Published date:
06/14/2022
Excerpt:
Comprehensive proteomic and drug-screening studies across pan-cancer models confirm that FAT1-mutant HNSCC exhibits selective and higher sensitivity to BRD4 inhibition by JQ1.
DOI:
10.1016/j.celrep.2022.110970
