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Association details:
| Biomarker: | FADD overexpression + BIRC2 overexpression |
|---|---|
| Cancer: | Squamous Cell Carcinoma of Head and Neck |
| Drug: | birinapant (IGM-9427) (IAP inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2
Excerpt:
Here we explore the potential and mechanisms by which HNSCC harboring amplifications and overexpression of FADD, without or with BIRC2...In vivo, birinapant inhibited tumor growth and enhanced radiation-induced TNFα, tumor responses, and host survival in UM-SCC-46 and -11B xenograft models displaying amplification and overexpression of FADD+/- BIRC2.
DOI:
10.1158/0008-5472.CAN-15-3317
