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Association details:
| Biomarker: | EWSR1-FLI1 fusion |
|---|---|
| Cancer: | Ewing Sarcoma |
| Drug Class: | CDK12 inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
5692 - Identification of novel CDK12 inhibitors that synergize with PARP inhibition through induction of ‘BRCAness’ phenotype
Published date:
05/15/2020
Excerpt:
...the cells showed a highly potent (IC50 < 10 nM) ability to induce cell death in the A673 cell line. A673 is a Ewing’s sarcoma cell line that expresses the EWS-FLI fusion protein and is therefore sensitive to CDK12 inhibition.
