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Association details:
| Biomarker: | ETV6-ABL1 fusion |
|---|---|
| Cancer: | B Acute Lymphoblastic Leukemia |
| Drug: | dasatinib (c-KIT inhibitor, Bcr-abl tyrosine kinase inhibitor, Src kinase inhibitor, EphA2 receptor antagonist, PDGFR β antagonist) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia
Published date:
03/11/2015
Excerpt:
The efficacy of dasatinib was also assessed in a xenograft model of ETV6–ABL1 ALL in which human leukemic cells were engrafted into immunodeficient mice. After 4 weeks of treatment, percentages of circulating human CD45+ cells were significantly reduced in the dasatinib-treated mice, as compared with vehicle-treated controls (17% vs. 88%, P<0.001), as was splenic weight (117 vs. 321 mg, P<0.001) (Fig. S17C in Supplementary Appendix 2).
DOI:
https://dx.doi.org/10.1056%2FNEJMoa1403088
