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Association details:
| Biomarker: | ER underexpression + ER Y537S |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | vepdegestrant (ARV-471) (Ubiquitin pathway modulator, Estrogen receptor alpha degrader) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
44 - The discovery of ARV-471, an orally bioavailable estrogen receptor degrading PROTAC®for the treatment of patients with breast cancer
Published date:
03/10/2021
Excerpt:
In an ESR1 Y537S, hormone-independent patient-derived xenograft model, ARV-471 at 10 mpk completely inhibited growth and also significantly reduced mutant ER protein levels.
