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DRUG:

vepdegestrant (ARV-471)

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Company:

Arvinas, Pfizer

Drug class:

Ubiquitin pathway modulator, Estrogen receptor alpha degrader

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ER positive	HER2 Negative Breast Cancer	ER positive	HER2 Negative Breast Cancer	ARV-471 Sensitive: B - Late Trials ARV-471 Sensitive : B	ARV-471 Sensitive: B - Late Trials ARV-471 Sensitive : B
ER positive + ESR1 mutation	HER2 Negative Breast Cancer	ER positive + ESR1 mutation	HER2 Negative Breast Cancer	ARV-471 Sensitive: C3 – Early Trials ARV-471 Sensitive : C3	ARV-471 Sensitive: C3 – Early Trials ARV-471 Sensitive : C3
ER positive	HER2 Negative Breast Cancer	ER positive	HER2 Negative Breast Cancer	palbociclib + ARV-471 Sensitive: C3 – Early Trials palbociclib + ARV-471 Sensitive : C3	palbociclib + ARV-471 Sensitive: C3 – Early Trials palbociclib + ARV-471 Sensitive : C3
ER underexpression + ER Y537S	Breast Cancer	ER underexpression + ER Y537S	Breast Cancer	ARV-471 Sensitive: D – Preclinical ARV-471 Sensitive : D	ARV-471 Sensitive: D – Preclinical ARV-471 Sensitive : D
ER underexpression	Breast Cancer	ER underexpression	Breast Cancer	ARV-471 Sensitive: D – Preclinical ARV-471 Sensitive : D	ARV-471 Sensitive: D – Preclinical ARV-471 Sensitive : D