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Association details:
| Biomarker: | EML4-ALK variant 3 |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug Class: | Angiogenesis inhibitor |
| Direction: | Resistant |
Evidence:
Source:
Title:
Patient-derived lung cancer organoids for the selection of therapeutic options in an ALK-rearranged tumor.
Published date:
05/19/2021
Excerpt:
A 54-year-old never-smoker man who had been diagnosed with lung adenocarcinoma stage IVa (T3N1M1a). He received standard first-line therapy with platinum-based chemotherapy, immunotherapy and antiangiogenics achieving tumor progression. A next-generation sequencing (NGS) panel revealed the presence of the EML4-ALK fusion variant 3a/b.
DOI:
10.1200/JCO.2021.39.15_suppl.e21014
