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Association details:
| Biomarker: | EGFR T790M + EGFR L833V + EGFR H835L |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug: | Gilotrif (afatinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Afatinib treatment response in advanced lung adenocarcinomas harboring uncommon mutations
Published date:
09/21/2021
Excerpt:
...the effectiveness of afatinib in patients with stage IIIB/IV lung adenocarcinoma...Molecular profiling reports of 16 afatinib-resistant biopsy samples were available, and the secondary T790M mutation was detected in one patient with L833V/H835L mutation and one harboring S768I/L858R mutation.
DOI:
10.1158/2159-8290.CD-21-0715
