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    Association details:
    Biomarker:EGFR R776H + EGFR L861Q
    Cancer:Non Small Cell Lung Cancer
    Drug:Gilotrif (afatinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C4 – Case Studies
    Source:
    Lung Cancer
    Title:

    Two cases of non-small cell lung cancer patients with somatic or germline EGFR R776H mutation

    Published date:
    05/31/2021
    Excerpt:
    Here, we report two cases of NSCLCs with uncommon EGFR mutation R776H. One patient carrying somatic EGFR R776H and L861Q was treated with afatinib and achieved a durable response.
    DOI:
    10.1016/j.lungcan.2021.05.036