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Association details:
| Biomarker: | EGFR overexpression |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | Erbitux (cetuximab) (EGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines
Excerpt:
We assessed the activity of cetuximab in five gastric cancer cell lines (AGS, KATOIII, MKN1, MKN28 and MKN45)….High EGFR expression and low levels of receptor activation were associated with cetuximab responsiveness….
DOI:
10.1007/s00432-011-1128-4.
