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    Association details:
    Biomarker:EGFR overexpression
    Cancer:Esophageal Squamous Cell Carcinoma
    Drug:LR004-VC-MMAE (Microtubule inhibitor, EGFR-targeted antibody-drug conjugate)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Mol Oncol
    Title:

    An EGFR-targeting antibody–drug conjugate LR004-VC-MMAE: potential in esophageal squamous cell carcinoma and other malignancies

    Excerpt:
    In the same type of tumor cells (ESCC, NSCLC, breast cancer), the EGFR-overexpressing cancer cells were more sensitive to LR004-VC-MMAE than the EGFR low-expressing cells, in terms of the IC50 values.
    DOI:
    https://doi.org/10.1002/1878-0261.12400