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Association details:
| Biomarker: | EGFR overexpression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | LR004-VC-MMAE (Microtubule inhibitor, EGFR-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
An EGFR-targeting antibody–drug conjugate LR004-VC-MMAE: potential in esophageal squamous cell carcinoma and other malignancies
Excerpt:
In the same type of tumor cells (ESCC, NSCLC, breast cancer), the EGFR-overexpressing cancer cells were more sensitive to LR004-VC-MMAE than the EGFR low-expressing cells, in terms of the IC50 values.
DOI:
https://doi.org/10.1002/1878-0261.12400
