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Association details:
| Biomarker: | EGFR overexpression + HER-2 overexpression |
|---|---|
| Cancer: | Cholangiocarcinoma |
| Drug: | varlitinib (ASLAN001) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
In vitro and in vivo Anti-Tumor Effects of Pan-HER Inhibitor Varlitinib on Cholangiocarcinoma Cell Lines
Excerpt:
Elevated expressions of EGFR and HER2 were observed in KKU-214 and KKU-100 cells...KKU-214 was subcutaneously injected into athymic BALB/c nude mice after which the mice were administrated with varlitinib...The results showed that 50 mg/kg and 100 mg/kg of varlitinib significantly suppressed tumor growth...
DOI:
https://dx.doi.org/10.2147%2FDDDT.S250061
