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Association details:
| Biomarker: | EGFR overexpression + BRAF mutation |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | HTI-1511 (Microtubule inhibitor, EGFR-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
HTI-1511, a novel anti-EGFR-ADC, overcomes mutation resistance and demonstrates significant activity against multiple tumor types in preclinical studies
Excerpt:
Here we screened a panel of over 70 tumor cell lines derived from various solid tumor malignancies for both EGFR expression by flow cytometry and sensitivity to cell growth inhibition by HTI-1511 in vitro....An initial study evaluated weekly administration of a single dose level of 2.5 mg/kg HTI-1511 in three different PDX models. TGI of 83% (p<0.05) was observed in a BRAFmut colorectal cancer model and 57% (p<0.05) in a wildtype colorectal cancer model…These results support further development of HTI-1511 as a possible treatment for EGFR overexpressing tumors, including those with downstream activating mutations in the KRAS/BRAF pathway.
DOI:
https://doi.org/10.1158/1538-7445.AM2017-50
