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Association details:
| Biomarker: | EGFR N771delinsKG |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | Gilotrif (afatinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Response to Afatinib in a Patient with NSCLC Harboring Novel EGFR Exon 20 Insertion Mutations
Published date:
01/12/2021
Excerpt:
After the treatment of afatinib, one lesion in left lower lung became obscure and unmeasurable, and the tumor size of the other lesion in right chest decreased to 43.7 mm 37.2 mm. According to the response evaluation criteria in solid tumors (RESIST 1.1), she achieved a radiological partial response (PR)...the first case of a patient with NSCLC harboring a novel EGFR exon 20 insertion mutation (p. N771delinsKG), who benefited from afatinib.
