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Association details:
| Biomarker: | EGFR mutation |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | M1231 (Microtubule inhibitor, EGFR-targeted antibody-drug conjugate, MUC1-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Preclinical studies of the bispecific MUC1xEGFR antibody drug conjugate M1231 in EGFR mutant NSCLC
Published date:
10/10/2022
Excerpt:
M1231 potently inhibited cell viability of EGFR mutant and TKI resistant NSCLC cell lines with subnanomolar to single digit nanomolar IC50 values….M1231 induces G2/M arrest and potently inhibits cell viability in a range of EGFR mutant NSCLC cell lines, including those resistant to TKIs.
DOI:
https://doi.org/10.1016/S0959-8049(22)01035-8
