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Association details:
Biomarker:EGFR mutation
Cancer:Non Small Cell Lung Cancer
Drug:IK-930 (TEAD1 inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

IK930, a novel TEAD inhibitor, sensitizes KRAS and EGFR mutant tumors to oncogene targeted therapy

Published date:
10/12/2022
Excerpt:
Consistently, combination of IK-930 with MEKi and EGFRi resulted in apoptosis in vitro and led to strong antitumor activity in vivo in KRAS and EGFR mutant xenografts models of CRC and NSCLC.
Secondary therapy:
EGFR inhibitor; MEK inhibitor